| POS | LW | MOVIE TITLE | WEEKS | WEEKEND | GROSS |
| 1 | - | Iron Man | 1 | $98,618,668 | $102,118,668 |
| 2 | - | Made of Honor | 1 | $14,756,850 | $14,756,850 |
| 3 | 1 | Baby Mama | 2 | $10,065,010 | $32,062,480 |
| 4 | 2 | Harold and Kumar Escape from Guantanamo Bay | 2 | $6,114,373 | $25,369,337 |
| 5 | 4 | Forgetting Sarah Marshall | 3 | $6,059,920 | $44,732,340 |
| 6 | 3 | The Forbidden Kingdom | 3 | $4,187,897 | $45,112,303 |
| 7 | 5 | Nim's Island | 5 | $2,677,543 | $42,471,660 |
| 8 | 6 | Prom Night | 4 | $2,403,313 | $41,350,731 |
| 9 | 7 | 21 | 6 | $2,002,471 | $78,959,237 |
| 10 | 8 | 88 Minutes | 3 | $1,545,084 | $15,368,925 |
| 11 | 9 | Horton Hears a Who! | 8 | $1,337,562 | $149,817,680 |
| 12 | 10 | DECEPTION | 2 | $883,417 | $4,000,654 |
| 13 | 19 | Drillbit Taylor | 7 | $730,231 | $31,164,888 |
| 14 | 11 | Street Kings | 4 | $708,142 | $25,133,327 |
| 15 | 13 | Expelled: No Intelligence Allowed | 3 | $678,304 | $6,613,256 |
| 16 | 16 | The Visitor | 4 | $606,597 | $1,576,256 |
| 17 | 12 | Leatherheads | 5 | $572,320 | $30,332,745 |
| 18 | 14 | Smart People | 4 | $325,787 | $8,943,977 |
| 19 | 28 | Young@Heart | 4 | $315,357 | $925,669 |
| 20 | 17 | Shine a Light | 5 | $278,006 | $4,846,348 |
| 21 | 45 | Then She Found Me | 2 | $222,000 | $316,000 |
| 22 | 29 | The Spiderwick Chronicles | 12 | $212,364 | $71,148,699 |
| 23 | 25 | THE COUNTERFEITERS | 11 | $204,303 | $4,440,307 |
| 24 | 15 | Superhero Movie | 6 | $202,879 | $25,263,751 |
| 25 | 20 | Under the Same Moon | 7 | $193,182 | $12,102,872 |
| 26 | 23 | Fool's Gold | 13 | $167,202 | $69,864,325 |
| 27 | 22 | 10,000 B.C. | 9 | $152,182 | $93,644,301 |
| 28 | 21 | Tyler Perry's Meet the Browns | 7 | $148,506 | $41,939,392 |
| 29 | 36 | Never Back Down | 8 | $145,658 | $24,569,276 |
| 30 | 18 | The Ruins | 5 | $141,870 | $16,939,323 |
