| POS | LW | MOVIE TITLE | WEEKS | WEEKEND | GROSS |
| 1 | - | Transformers 2: Revenge of the Fallen | 1 | $108,966,307 | $200,077,255 |
| 2 | 1 | The Proposal | 2 | $18,578,541 | $69,162,471 |
| 3 | 2 | The Hangover | 4 | $17,022,166 | $183,054,267 |
| 4 | 3 | Up | 5 | $13,061,737 | $250,234,554 |
| 5 | - | My Sister's Keeper | 1 | $12,442,212 | $12,442,212 |
| 6 | 4 | Year One | 2 | $6,022,444 | $32,529,560 |
| 7 | 5 | The Taking of Pelham 123 | 3 | $5,451,107 | $53,456,827 |
| 8 | 7 | Star Trek | 8 | $3,711,968 | $246,331,182 |
| 9 | 6 | Night at the Museum 2 | 6 | $3,643,522 | $163,391,192 |
| 10 | 13 | AWAY WE GO | 4 | $1,709,313 | $4,088,390 |
| 11 | 8 | Land of the Lost | 4 | $1,195,685 | $46,815,665 |
| 12 | 11 | Angels and Demons | 7 | $1,091,953 | $130,277,166 |
| 13 | 10 | Terminator Salvation | 6 | $1,088,392 | $121,925,747 |
| 14 | 9 | Imagine That | 3 | $942,273 | $14,067,015 |
| 15 | 12 | Drag Me to Hell | 5 | $583,215 | $40,536,230 |
| 16 | - | New York, I Love You | 1 | $467,694 | $467,694 |
| 17 | - | Cheri | 1 | $405,701 | $405,701 |
| 18 | 26 | Monsters vs. Aliens | 14 | $365,080 | $195,984,055 |
| 19 | 20 | WHATEVER WORKS | 2 | $359,805 | $738,969 |
| 20 | 14 | X-Men Origins: Wolverine | 9 | $310,167 | $177,836,819 |
| 21 | 17 | FOOD, INC. | 3 | $291,444 | $834,848 |
| 22 | 21 | Dance Flick | 6 | $270,102 | $25,135,830 |
| 23 | 19 | UNDER THE SEA 3D | 20 | $254,651 | $10,970,772 |
| 24 | 16 | Easy Virtue | 6 | $245,423 | $2,024,412 |
| 25 | 32 | Hannah Montana: The Movie | 12 | $190,893 | $78,578,891 |
| 26 | 18 | 17 Again | 11 | $178,800 | $63,117,832 |
| 27 | - | THE HURT LOCKER | 1 | $145,352 | $145,352 |
| 28 | 23 | THE BROTHERS BLOOM | 7 | $131,504 | $3,114,901 |
| 29 | 24 | The Soloist | 10 | $126,488 | $31,527,902 |
| 30 | 22 | Ghosts of Girlfriends Past | 9 | $126,269 | $53,666,193 |
