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heard someone said the settings and plots are totally different
haven't read spiderman comics for a long time...need some updates

Well, it basically starts same as 616 Spiderman, but it has many differences. Etc. The Ultimate Green Goblin is a hulking monster, villain origins are different, some characters look different...you get the point. It is a good comic in my opinion, so you should read it. You can read first 3 comics from here.

oh~ thx man

its marvel last stand, to get out of the hole they digged screwing spidey comics history, venom comics are the same