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These three are working together to take down the big boys in Marvel and D.C.: Professor X, Dr. Strange, and Dr. Doom. Featureless environment, no prep time, and the three have a basic understanding of their opponents abilities.
Who can beat them:

Superman

Hyperion (Exiles and non-Exiles verions)

Thor

Hulk

Wonder Man

Wonder Woman

Captain Marvel

Gladiator