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High E,Mister F and Adam Warlock have 3 week of prep. No Infinity Gautlets or Ultimate Nulifier accept the soul gem but really just there combined brains technology and powers. Each of the three can have help from one friend but nobody above cosmic entity Level.

High Evolutionary- http://en.wikipedia.org/wiki/High_Evolutionary

Adam Warlock- http://en.wikipedia.org/wiki/Adam_Warlock

Mister Fantastic- http://en.wikipedia.org/wiki/Mister_Fantastic

3 weeks of prep for Reed

Reed wins

I would but High E equal to or smarter the Mister F

huhm what chance have they got alot with those brains they can prob think of a way to depower the other 2