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Can the tough villains defeat Impossible Man?

no yes - dont no really

Would Bio's help?

Impossible Man is pretty much impossible to beat.

I honestly cannot see anyone below Thanos taking him down in a real fight

I know but SA was able to Adapt a silver of a cosmic Cube into him making very powerful so I think he has the ability to win but maybe not the experience to win.

imp wins

hmm connection to mr mxy