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Who wins?

Zeus- http://en.marveldatabase.com/Zeus_%28Earth-616%29

Osiris-
http://en.marveldatabase.com/Osiris
&

Zuras- http://en.marveldatabase.com/Zuras

vs

Destroyer- http://en.marveldatabase.com/Destroyer_%28Enchanted_Armor%29

Destroyer.

Odin/Destroyer was built to combat the Celestials

Odin/Destroyer FTW

How well did it do?

Celestial host reduced it to molten slag

Celestials>Asgardians

So that being said it might be Celestial in in size but not power. I think it would be a good fight You have three rather powerful characters skyfathers to be exact.

You had three powerful skyfathers against a Single Celestial and they got humbled, the Destroyer most likely isn't equal to a single Celestial but it isn't far from, and suceed in harming the Celestials more then three skyfathers combined could.