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Nice.

Originally posted by Bardock42
Nice.

Here's another kid with it, he's even one of your own.

http://www.sixwise.com/newsletters/07/02/28/myostatin-blockers-the-potential-benefits-and-risks-of-these-forthcoming-super-muscle-drugs.htm

Well, by all accounts the kid does indeed seem to be super human.

I'm too lazy to find out for myself, so I'll just ask.

Is there any side effectts of this condition? Shortened life-spans, mutating into big orange monsters, etc?

I want this condition.

Read the New Gods by Jack Kirby.

Or watch Unbreakable by M. Night.

Originally posted by WrathfulDwarf
Read the New Gods by Jack Kirby.

Or watch Unbreakable by M. Night.

That's fiction, this isn't.

Originally posted by Robtard
That's fiction, this isn't. And I get Unbreakable, but how do New Gods relate....

Originally posted by Robtard
That's fiction, this isn't.

Then don't read it...simple.

Originally posted by Blax_Hydralisk
Well, by all accounts the kid does indeed seem to be super human.

I'm too lazy to find out for myself, so I'll just ask.

Is there any side effectts of this condition? Shortened life-spans, mutating into big orange monsters, etc?

It's not certain, low body fat in babies can slow learning and brain developement though.

The dog(s) that has it, is said to have a shorter lifespan, but that may not translate to humans.

Originally posted by WrathfulDwarf
Read the New Gods by Jack Kirby.

How is this anything like New Gods?

Originally posted by Toku King
How is this anything like New Gods?

They're beings of genetic stability and evolutionary perfection.

My comment wasn't intended to be an indepth study into the works. Just a simple note that the possiblity of highly genetic people have been with us for quite a while.

Originally posted by WrathfulDwarf
They're beings of genetic stability and evolutionary perfection.

My comment wasn't intended to be an indepth study into the works. Just a simple note that the possiblity of highly genetic people have been with us for quite a while. Yeah, not the real world possibility in such a clearness at least.

Originally posted by WrathfulDwarf
They're beings of genetic stability and evolutionary perfection.

My comment wasn't intended to be an indepth study into the works. Just a simple note that the possiblity of highly genetic people have been with us for quite a while.

See, that you you've explained it a bit, it relates somewhat. Lance Armstrong's heart being an example of being genetically superior.

Originally posted by WrathfulDwarf
They're beings of genetic stability and evolutionary perfection.

My comment wasn't intended to be an indepth study into the works. Just a simple note that the possiblity of highly genetic people have been with us for quite a while.

Which is an even better reason for them to have an arch enemy, aka me! Now all I need to do is wait twenty years, and when he becomes a superhero, I'm going to have all sorts of henchmen and evil schemes, most in plans to steal his great power and use it for evil!

The Liams will one day take over the world

Originally posted by WrathfulDwarf
They're beings of genetic stability and evolutionary perfection.

Considering their most powerful members are not powered by anything inherent to them and even then get stalemated by mortals I am forced to question the basis of that assertion.

Originally posted by Robtard
It's not certain, low body fat in babies can slow learning and brain developement though.

Great, we're going to have retarded pasty Hulks wandering around.

I thought this was a joke but since it's not, I'm laughing in amazement. Is this what most future babies will be like? Let's hope so. We already have too many diseases and stuff going around so if this baby could help us find cures, that'd be remarkable.

Originally posted by Blax_Hydralisk
is there any side effectts of this condition? Shortened life-spans, mutating into big orange monsters, etc?

I read something about this but I couldn't remember where.

I found it..

In a study done on myostatin deficient mice, it was found that they had more brittle tendons. Stronger/larger muscles coupled with more brittle tendons would normally equate to "muscles tears" at the insertion. However, I disagree, slightly, with the study conducted. The mutation that was responsible for myostatin deficiency may simply be a mutation that is affecting multiple mechanisms including scleraxis and tenomodulin. This trait(or rather, traits) the attributes itself to a myostatin deficiency was, in my opinion, erroneously assigned as a sympathetic mechanism for tendon weakness. In other words, the inheritance of myostatin deficiency in mice may come with other genetic baggage. Myostatin deficiency in other animals is not found with an accompaniment of weakened tendons. So, this may simply be an incidental mechanism to myostatin deficiency due to the genetic data passed on with the mutation. I could be utterly wrong and there are sympathetic paths affected by myostatin to some how get back to the tendons. (Which seems to be the mindset of the conclusion in this study.) Also, not all of the "mice" studies translate into the human body.


Here's the abstract of the study on the mice:

http://www.pnas.org/cgi/content/abstract/105/1/388?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Myostatin%2C+mice&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT



One thing of worthy note:

It would appear the myostatin deficiency, or rather, the effect of myostatin deficiency in the form of hypertrophy is not extended to cardiac muscles. This means the heart does not appear to experience the same hypertrophic effects the skeletal muscles do. As many of you may be aware, an enlarged heart is dangerous. As the muscles become larger, the chambers becomes smaller so your heart has to work harder to turn out the same volume of blood. Because the paths associated with the hypertrophically suppressive paths that myostatin affects, one would expect the cardiac muscles to be affected (from a myriad of mechanisms such as cell site receptors held in common with cardiac and skeletal muscles), but it has not been observed, which is excellent for muscular dystrophy patients and athletes.

With selective androgen receptor modulators (SARMs) and myostatin gene inhibitors on the horizon, we can look forward to magic muscles pills from the pharmaceutical industry that will make anabolic steroids look like dirty home-remedies.



There are super humans among us. Or rather, those humans that exhibit more favorable genetic dispositions. There is something very real about the story in "Unbreakable": there ARE humans at the opposite ends of the genetic spectrum.

One is born with muscular dystrophy, the other is born with myostatin deficiency.

Just like I've said in previous threads, genetically engineering our children is NOT science fiction. We will pick and chose our children's traits via genetic mechanisms. Gene doping is already here. The next step will be "womb doping".(That's my own term...you "heard" it here first, folks.)

That's all very interesting. I can safely say we have officially reached the next stage of human evolution.

Originally posted by Stewie_Griffin
That's all very interesting. I can safely say we have officially reached the next stage of human evolution.

And I want it! Mwahahaha!

Now all I need is henchmen and a power draining device.

Originally posted by Toku King
And I want it! Mwahahaha!

Now all I need is henchmen and a power draining device.

It's called kids and a wife, respectively.

Originally posted by dadudemon
It's called kids and a wife, respectively.

my wife has magic powers (she can make my money disappear)

Toku, you're not funny. And if you were a villain, you'd be the type to always fail at your missions, only to be mocked and laughed at by society. The police probably wouldn't even bother trying to capture you.

hey i am a cop and i would not

Originally posted by Stewie_Griffin
Toku, you're not funny. And if you were a villain, you'd be the type to always fail at your missions, only to be mocked and laughed at by society. The police probably wouldn't even bother trying to capture you.

So I'd be you in a costume, then?

Originally posted by KMC's Superboy
my wife has magic powers (she can make my money disappear)

rofl2

I love it when you try to do that. It's so funny. C'mon! Do it again!

Originally posted by Stewie_Griffin
I love it when you try to do that. It's so funny. C'mon! Do it again!

Aww, someone's trying to act superior! How cute! It's like a lost puppy!

Originally posted by Zeal Ex Nihilo
I vote we breed the kid and sell his children for cheap labor. He'll be like a Mexican, except he'll be good at things.
lollerpwnd

Originally posted by Blax_Hydralisk
Is there any side effectts of this condition?
I would think that likely. Life is "funny" like that, and people (especially those with visions of superhumans dancing in their heads) tend not to see the larger picture.

My guess is, before we can create actual superhumans (via genetics, nanotech, whatever), we're going to need a very comprehensive and detailed grasp of countless factors, many (if not most) of which we probably aren't even aware of at this time.

Truly, the first thing we should breed out of our race is egoic shortsightedness.

Originally posted by Mindship


Truly, the first thing we should breed out of our race is egoic shortsightedness.

Also unfounded massfear and hysteria.

Originally posted by dadudemon
It's called kids and a wife, respectively.

Originally posted by Robtard
Here's another kid with it, he's even one of your own.

http://www.sixwise.com/newsletters/07/02/28/myostatin-blockers-the-potential-benefits-and-risks-of-these-forthcoming-super-muscle-drugs.htm

German super soldier serum. Wonder if he has a liking for all things poop?

this Liam kid is gonna be the real life Steve Rogers

Originally posted by Mindship
Truly, the first thing we should breed out of our race is egoic shortsightedness.

Then we can add intelligence. After that we'll purify with white race.

Originally posted by jalek moye
this Liam kid is gonna be the real life Steve Rogers

They're going to pump him full of steroids, a yet unknown chemical, give him a funky suit (complete with shield) and send him to punch Hitler in the teeth?

Or is he going to play in the MLB All-Star Game five times?

This condition sounds like a good thing unless you experience food shortage.

Originally posted by Stewie_Griffin
That's all very interesting. I can safely say we have officially reached the next stage of human evolution.

Well, I guess the judge has ruled. All pencils down folks, time has run out.

Yes, it has.

Have any other cases similar to this been discovered?

Originally posted by Symmetric Chaos
Then we can add intelligence. After that we'll purify with white race.



They're going to pump him full of steroids, a yet unknown chemical, give him a funky suit (complete with shield) and send him to punch Hitler in the teeth?

Or is he going to play in the MLB All-Star Game five times?
yup the first one only its gonna be some al queda leader and he already has the chemical in his body

Superhumans will be here.

Master Chief

its a possibility that may not be that far from the truth, bizaare as it sounds.

I am the first true superhuman, no lie.

galan_wonderwmn1m galan_superman1m

i think that would make my life complete. RL superheroes. I'm all for genetic enhancement W00T!

This development makes me happy, as my stock in Ryan Industries has not been performing well over the past couple of decades.

Gene says almost about Live creature They r causes all our activity not truly but 50% in rough idea Awi
I accept &it is probably true that These gene may causes some extra feature which is some time very strange & creature get too energiged then normal condition.
This may makes a persone as Super Having Some extra ordanary natural power

"All your base are belong to us" or just a sock, that is the the question. Whether 'tis nobler in the mind to suffer the slings and arrows of outrageous fortune, or to take arms against a sea of troubles, and by opposing end them?

I have a super power I can drink more beer than anybody! beer

Why couldnt i been born with this?

Because your black.

Racist pig.

Originally posted by Blax_Hydralisk
Because your black.

Genetic denial!

Originally posted by Da Joker
Racist pig.

Your Moms a racist pig.

Though you're also a bigot. So you should STFU.

I'm not a bigot, and nice comeback with the mom joke. Really shows the intelligence coming off of you.

I bet your mom's some hick who got sexed up by her dad and had you. STOP INBREEDING! IT'S NOT COOL!

You are a bigot. I've seen your dumbass posts in the boobs thread. Don't lie.

Increased muscle mass at such a young age can lead to skeletal deformities, as well as the risk of slowed learning due to half the body fat compared to an average child.

'One possible concern, according to Dr. Markus Schuelke, the pediatric neurologist at Charite University Medical Center in Berlin who discovered the myostatin mutation in the baby, is that blocking myostatin could interfere with satellite cells that help replace injured or dead muscle cells. It's thought that myostatin helps keep the satellite cells at rest until they're needed, and it's possible that without myostatin the satellite cells could become depleted.

Meanwhile, some say myostatin blockers may be too targeted to boost muscle growth, as there are a variety of proteins similar to myostatin that also limit muscle growth.

Another drug company, Acceleron Pharma, is planning to test a drug on humans that reportedly blocks not just myostatin but also many of the other similar proteins.'

It's going to be interesting keeping up with what happens to this child.

Apparently they are also looking in to developing myostatin blockers as a new form of steroids. I cant believe this shit, already they are looking to exploit it.

Originally posted by Blax_Hydralisk
You are a bigot. I've seen your dumbass posts in the boobs thread. Don't lie.

Nah, I'm not. But isn't if just fun to use words to which you don't know the meaning?

Is it fun to have the grammar and spelling ability of a six-year old?

Y3p, itz sur3sz isz. I cantz sp3llz worthz a shtz and im just a litlte thr33 y3ar old.

We know.

It's good to know things, isn't it? Now, if you can comprehend, I think it's best to get back to what this topic was intended for, which wasn't your horrible blather.

Originally posted by Da Joker
I'm not a bigot, and nice comeback with the mom joke. Really shows the intelligence coming off of you.

I bet your mom's some hick who got sexed up by her dad and had you. STOP INBREEDING! IT'S NOT COOL! ...Did you just insult him for doing a mom joke, then made a mom joke to insult him?

Your fail levels are reaching levels to high. You must stop posting on the internetz or else your fail level will eventually corrupt and destroy it.

Oh, and as for you not being a bigot, lol, you claimed gays get sent to hell and castrated and said men that don't like women are not real men at all. Lol. Bigot.

And as for this thread...Yeah the kid seems to be pretty super for a human. Though as Kosta pointed out later he may be affected by it negatively.

I can do this stuff, because I'm me. If you guys don't like me I'm not forcing you to respond. But the more you do, the more stupid and utterly ridiculous claims I'll make.

The sky is red. **** that blue sky shiznit, it's red.

Originally posted by Kosta
'One possible concern, according to Dr. Markus Schuelke, the pediatric neurologist at Charite University Medical Center in Berlin who discovered the myostatin mutation in the baby, is that blocking myostatin could interfere with satellite cells that help replace injured or dead muscle cells. It's thought that myostatin helps keep the satellite cells at rest until they're needed, and it's possible that without myostatin the satellite cells could become depleted.

Does that doctor have any studies to show for that information? Professional opinion is great and all, but an actual legit study or two would be much much better. I'm getting a different story. Such as POTENTIAL weakening(or weaker, relative to the "average" of connective tissues (tendons). I've posted my sources already for my information. It would be nice if your doctor had some. If it's just a guess on the doctor's part, great...there's plenty of other mammals out there who are similarly affected by the lack of myostatin as this child. Maybe she could study those animals and see if her ideas have credibility?

Originally posted by Kosta
Meanwhile, some say myostatin blockers may be too targeted to boost muscle growth, as there are a variety of proteins similar to myostatin that also limit muscle growth.

The inhibitive effects of the myostatin gene expression is pretty straight forward. Sure, there's a myriad of other factors involved in muscular hypertrophic suppression, but myostatin's role is pretty straight forward. So, are those "some" that you're listening to basing what they say on sound science? A quick search on myostatin would net you contradictions, of course.

Originally posted by Kosta
Another drug company, Acceleron Pharma, is planning to test a drug on humans that reportedly blocks not just myostatin but also many of the other similar proteins.'

ACE-031, to be exact. It's primary method of effectiveness(I swear, there's a technical term for those last three or four words...I just can't remember it off the top of my head ) is most likely myostatin inhibition. There's quite a few things that could be targeted to help enhance muscle growth, but myostatin inhibition seems to be absurdly effective. We could go on all day about all the different little things the body does to positively and negatively affect muscular hypertrophy. There's a multi billion dollar supplement industry out there exploiting them to some degrees.

I'm not too sure but I thought it was much much harder to measure a drug's effectiveness (any pharmaceutical counteractions that might occur, toxicity that manifests between two different drugs simultaneously doing their modulation thang, etc.) to make excellent measurements of the effects of the pharmaceuticals, and getting it FDA approved. It's not the same as binding the active ingredient to a sustained release system and getting yourself another 15 years of exclusivity on the "new" form.

I'd like to know more about the contents of this drug, but I don't expect much because those drug companies like to keep that shit tight lipped to keep others from developing similar items before the "originals" are done.

Originally posted by Kosta
It's going to be interesting keeping up with what happens to this child.

So, do we have manifestations in any form of deformed bones or diminished cognitive abilities? (relative to the population, of course!) He's 4 now, isn't he? Surely that's more than old enough to observe these types of negatives?

Originally posted by Kosta
Apparently they are also looking in to developing myostatin blockers as a new form of steroids. I cant believe this shit, already they are looking to exploit it.



That last part was misplaced fear mongering. Don't fall victim of the 'steroid fear craze", please. You're much worse off smoking a pack a day then intelligently running testosterone ethanate through your body in cycles ("intelligently" implies that you're watching out for aromitization, can't be having too much estradiol, right?) . Seriously. In fact, in some cases (could be a "most" in America), doing the latter could actually improve health. EGADS! But steroids are bad for you, aren't they? pppffffffffff

Back on topic, what exactly is wrong with taking a drug that inhibits one of the major elements that puts a nice death grip on muscular hypertrophy that has shown little side effects in human clinical trials? You do know that they have some in clinical trials now, don't you?

Here's one that I found in a split second.

http://www.medicalnewstoday.com/articles/20441.php

I've read about these clinical trials. (I could be reading about the same pharmaceuticals, though.) They seem very promising. Almost too good to be true. All the benefits of anabolics with little to no side effects? Sign me up when the cookies are DONE!

And, no, I don't take any anabolic steroids, HGH, etc. in anyway shape or form. Waaay too damn expensive...and I don't want to have to mess with shit like cycles, injections, clomid and on and on and on. Side effects are not really appealing anyway.

BTW. "Flex" Wheeler has a myostatin "problem": he doesn't produce very much of it. He's never torn a muscle, though I'm not sure this "tendon" problem is that much of a "problem". However, I'll remain skeptical until I have better concrete data.


P.S. If there's mistakes in this post, great. I didn't bother proofreading . I've also taken some liberty on "common knowledge" that is not "common knowledge" at all. Google can make it "common" if used, though.

Originally posted by Da Joker
I can do this stuff, because I'm me. If you guys don't like me I'm not forcing you to respond. But the more you do, the more stupid and utterly ridiculous claims I'll make.

The sky is red. **** that blue sky shiznit, it's red.

And then eventually you'll just get banned.

So I suppose we should keep on then.

a super baby? a mini arnold

I don't think it is a possibly at all but who knows maybe the goverment has something underwraps.As much fun it would be to believe that there really are superheros out there I would have to say that I don't think it can be done.

All I can say is thank you, Jackie, for coming back to the GDF! This forum has been missing so much juvenile obviousness since you've been gone. Thank you!

And I been missing alot of your pointless threads and answears as well so thanks you as well!

Originally posted by dadudemon
It's called kids and a wife, respectively.

That's gold, Jerry. Gold.