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http://media.comicvine.com/uploads/0/760/87973-9237-saint-of-killers_super.jpg vs http://media.comicvine.com/uploads/0/8015/191852-199031-spectre_super.gif

I think that if the Spectre is NOT fully backed by the Presence, he's in for a world of hurt'n. I mean, come on, not even angels or demons were safe from the Saints guns. Not even God or the Devil for that matter. However, if he in fact IS fully backed, I see the Saint of Killers getting erased from existance. Now, the only real question is, is the God/Devil in the SOK comics equal to the Presence/GEB? I personally don't think so. Anyway, that's my take on it.

SOK one shots him.