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Black Jack, the protagonist of the anime/manga series of the same name.

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vs.

Spike Spiegel, the protagonist of the anime/manga series Cowboy Bebop.

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Both can use their standard weapons.

Hmm, Black Jack's a surgeon right? He'll need to have done some serious shit to keep up with Spiegel. He's peak-human at worst. Need feats for BJ.

Black Jack can actually fight? O_o

I hadn't seen Black Jack fight but from what I read so far, he can hold his own in a fight. He uses his scalpel like a shuriken and he also carries a gun.