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http://media.comicvine.com/uploads/3/31566/900195-new_fearsome_five_large.jpg

vs

http://media.comicvine.com/uploads/0/8190/262728-19829-sinister-six_large.gif

Nano? Rumble? Those're new ones on me...

*Looks them up*

Hm, both armor-users, Nano's a cyborg foe, Rumble uses sound but the wiki page doesn't say a lot...

Mammoth's the strongest person on the field and the Five may edge out in power (assuming we're talking classic, not modern Electro on the Six's side), but the Spidey villains are more competent and IMO'll work together better. Good fight.