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Elaine Belloc who is the daughter of Michael and her uncle is Lucifer Morningstar versus The Endless family. She decides it's time to rewrite another Cosmos. Can she do it?

Elaine
http://en.wikipedia.org/wiki/Elaine_Belloc

Endless Family
http://en.wikipedia.org/wiki/Endless_(comics)

Yes. She made her own creation, one in which (presumably) she did not create the Endless.

But anyways, she bears Michael's power, and thus could destroy all of creation and with it, the Endless.

Elaine is the Presence.

Presence >>>>>>>>>>>>>> The Endless.

Elaine stomps a hole in them pretty much effortlessly if she wants.

elaine

In her regular angelic/human form she would be nothing to them. If she has Michaels power she would still be half human so that would be harder to say. If we use her as when she is being used and has taken over for The Presence/God then she would win.