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In a physical brawl.

Both bloodlusted - Harley thinks Selina is out to steal Mistah J from her, while Selina thinks Harley murdered all her pet cats.

Who wins?

Selina should win.

DCnu or DCU?

Harley is too unpredictable, Selina is more deliberate.

I see Selina messing with Harley until Quinn gets reckless and then ending it swiftly with a bestial tongue lashing of one-liners to follow.

Harley should take it she faster than Selina

Pre reboot, Harley definitively.

Post? Not sure...

This is how the battle goes :
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No punch glove or any gadgets for Harley.

And no whip for Selina. But I suppose her claws are part of her costume, so that's allowed.