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Ezio is extremely sick so Connor has to temporarily take over. He has his standard weapons (Tomahawk, hidden blades, bow, sword & knives). Does he survive the war against the Borgia and Templars?

..Hm.

He's certainly capable in body, more so than Ezio, but to get where Ezio did he had to be his open self, not so much the lone wolf Connor is.

Connor has the obvious potential to do this, its just his execution and personal flavour that might trip him up.