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Alright,

The Guardian of Nature vs. the Sorcerer Supreme.

Fight!!!

I'm assuming pre-reboot ST and classic Strange at his best?

Yes of course.

At their peaks all capabilities available? Probably stalemate when strange "becomes" swamp thing. Barring that and assuming both at peak levels ST in a horrific stomp. Top Knotch Classic Strange vs. pre-ret ST mid-upper level is a decent fight imo and comes down to whether or not a deity chooses to really give the Doctor that extra oomph in his fight to win it.

Giving it to Swampy