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Doomsday, as seen in the animated Superman vs Doomsday, invades Marvel Earth and begins laying waste to NYC. A team is assembled to stop him.

Avengers
Abomination
Loki
Kurse
Fantastic Four
Garfield Spiderman

Can they stop Doomsday?

This is after Doomsay resurrected from the fight with Superman. Going by the character's history, he can't be stopped the same way twice.

Kurse hits him with a black hole grenade.

Aside from black hole grenade, can he physically be stopped?