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Nate Drake from Uncharted 3(http://vignette2.wikia.nocookie.net/uncharted/images/4/4c/Uncharted_3_Boxart_-1-.jpg/revision/latest/scale-to-width-down/327?cb=20150626173733)

VS

Rambo from Rambo 4(http://www.imfdb.org/images/thumb/a/a4/RamboDVD.jpg/481px-RamboDVD.jpg)

Round 1: Straight gunfight in the ancient ruins of Amazon.
Weapons: Drake has a Machete, Wes-44 with 30 rounds, Pistole shotgun-pistol with 15 buckshot shells, AK-47 w/drum mag with 300 rounds and 5 Mini-NDI grenades.
Rambo has his Mini-Machete from Rambo 4, Colt M1911A1 with 40 rounds, Longbow with 15 arrows, M60E3 GPMG with 300 rounds and 5 M67 Frag Grenades.
Range: They starts against each other from 150 yards.

Round 2: Sniping Duel in the hills of Chernarus from ArmA 2.
Weapons: Drake has a Machete, PM-9mm with 40 rounds, Micro-9mm with 100 rounds and Dragon Sniper with 70 rounds.
Rambo has his Mini-Machete, Colt M1911A1 with 40 rounds, Compound Bow with 30 arrows and a Dragunov SVD with 70 rounds.
Range: They starts against each other from 600 yards.

Final Round: Hand-to-Hand with their barehands inside an steel caged ring.

Who wins and why?

Bump.

Drake wins because he's fought waves of enemies, survived things that should kill him and fought and won against magical shit for 3 games.

John's done about the same, save for the magic, for four movies. Longevity should not the key paradigm in determining the victor.

It's not the longevity, it's the scope and scale, which iirc Drake has much more under his belt and survives more impossible odds. Like lasting against immortal yetis.

Nathan would knock John Rambo out though, Gunfight's aside.