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Wesker from RE5.

VS

Chief from Halo series.

Round 1: They fights against each other with their standard weapons and gears.

Round 2: H2H without weapons.

The fight takes place inside the ship's hangar from RE5.

Wesker prolly stomps

Wesker stomps

Wesker can't get through John's armor.

Wesker gets his shit pushed in, his only advantage being speed is a minor one, once he gets hit by Chief (and he will get hit) he'll lose