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Round 1:
Andrew Garfield Spiderman vs Standard Commander Shepard

Round 2:
Comic Spiderman vs Commander Shepard with Biotic Armor

Shepard has M-8 Avenger, M-3 Predator, M-92 Mantis, Omni Tool and 3 Grenades. Round 2 same as this but shepard also has the Shield from ME Series.

Morals on

No BFR

No Speedblitz

New York City

Who wins?

The shield doesn't stop blows, Spidey should win unless his SS doesn't warn him of a Shepard trick.