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Can Jacen Solo, about halfway through the NJO series, defeat Quinlan Vos and Obi-Wan Kenobi one year into the Clone Wars?

Yes.

I remember some of the crazy stuff Jacen was doing like manipulating those Razor plants to shred the Vong in Traitor, and forming multiple telepathic bonds with the baby Yammosks and poisoning their minds so they kill each other (and bonding with the World brain that would eventually go to Coruscant). Morals off he could probably destroy Vos's mind.