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Round 1: Random encounter
Round 2: Wade gets that bag of weapons that he left on the cab

Who wins?

Colossus can knock out Wolverine pretty easily, so Logan wont be much of a problem. It comes down to Panther vs Colossus/Deadpool. Deadpool cant hurt BP, whereas BP can break each of his limb without too much trouble.

I think the main fight here is BP vs Colossus, and I'm not completely sure if either one can hurt the other.

Colossus doesn't have to hurt BP, he can just pin or otherwise immobilize BP.

He knocks out BP imo

We've still yet to see just how effective Panther's suit is. It stopped bullets and let him ignore Hawkeyes arrows, but would it shield him from getting a crack to the chest/skull from someone as strong as Colossus?

I don't if it hurt him but it look like WS hurt him on the airport.

Colossus/Deadpool wins...

As was correctly pointed out by Silent Master, Colossus can KO Logan and could just overpower Black Panther and immobilize him long enough for it to count for a forum win...

Originally posted by Silent Master
Colossus doesn't have to hurt BP, he can just pin or otherwise immobilize BP.