Death claims them. Or they fight the real God of Destruction. Or Destiny weit s then out of the narrative.
Um... While the GoD's are super powerful, and universal in scale...
The Endless are, as their name implies, Endless.
These are conceptual beings that operate on a scale so massive, that even the likes of multiversal beings like the classic Anti-monitor, Nekron, Dr. Manhattan, etc. are UTTERLY insignificant in comparison- to the point where they don't even register to the Endless.
The Endless are in the extremely small category of beings in all of fiction that can potentially oppose the likes of Michael Demiurgos, and Lucifer Morningstar. The only tier beyond that is the Presence, TOAA, otherwise known as "God" himself.
The GoD's in DBS wouldn't even begin to come close to reaching the realm of the Endless, even at their strongest. Not even all the angels put together could begin to reach the Endless.
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