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It can be any style whether comedy, drama, or something inbetween. What are some of your favorite movies where two friends drive across a country and learn about themselves or get into mischief?

Planes, Trains, and Automobiles has to be my best road trip film:
- Great balance between comedy and drama
- Lovable and believable characters
- Excellent plot structure and revelation near the end

Rain Man is up there.

I'll watch Todd Phillips' filmography of road movies as well (Road Trip, Euro Trip, Hangover, Due Date).

I liked Elizabethtown as well.

Clark Griswold ftw.

EuroTrip

Sex Drive.
Vacation.

The Road Warrior

Originally posted by Flyattractor
EuroTrip

I remember this as being one of the movies where Matt Damon makes one of his weird, out of place, cameos.

vTuA-xMead4

Originally posted by juggernaut74
Clark Griswold ftw. Originally posted by Flyattractor
The Road Warrior

I knew I forgot a couple. Add Fury Road to the top of my list.

Originally posted by TheVaultDweller
I remember this as being one of the movies where Matt Damon makes one of his weird, out of place, cameos.

vTuA-xMead4

Best part is the Green Fairy .

Two friends/people making their way in a vehicle?

Top five no particular order:
-Fear and Loathing In Las Vegas (1998) (Probably my #2)
-Planes, Trains & Automobiles (1987)
-Rain Man (1988) (Probably my #1)
-Natural Born Killers (1994)
-The Motorcycle Diaries (2004)

Edit: Honorable Mention

-Sideways (2004)

Kalifornia.

I always loved the "scotty doesn't know" part of Eurotrip lol.

Dumb and Dumber
Kingpin
Planes Trains Automobiles
Due Date
Rain Man
Me Myself and Irene

Though these don't strictly fall into the OP's parameters, my favorite movies that involve one or more people driving cross country include:

The Hitcher
Joyride
Duel

Originally posted by Surtur
I always loved the "scotty doesn't know" part of Eurotrip lol.

I found it highly amusing that it ends up becoming like a Worldwide hit, so it starts playing on the radio and things.

Or the other guy who pretends to be at work while going on the trip with them, and ends up getting a promotion while he is away.