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He can?

Sure, probably

He tanked anti-matter, along with CA's universe-busting quantum energies. So probably.

Hakai shouldn't work on beings more powerful than the user, so it really comes down to this question: according to you, is Superman Prime more powerful than full-power Beerus?

Both are beyond universal in raw power, flip a coin and pick your choice.

Yes, Prime gets erased

Tanks and asks for more