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Is Deadpool able to heal from step to step and make progress against any intellect?

Won't be as easy as a cheese sandwich that's for sure.

Nemesis probably shoots him with something that destabilizes his healing factor or something. Or turns him sane.

Well Indiana Jones did it in The Last Crusade. with steps.
Leap of faith.
https://www.youtube.com/watch?v=sBBbq2g7yf8