__________________ "Happiness is a lie. Life is horror. The light is always dying all across the universe. The last star will flicker out someday, when it does, all that remains is shadow. And I will be its king!"'-Amahl Farouk
Blade slices him up, Deadpool is skilled but if it weren't for his ability to regenerate and survive life-threatening injuries he'd lose a lot of the fights he got involved in.
Yeah. Blade is stronger than Wade, tougher than him, and has fought on even and superior footing with people way faster than him. He knocks Wade around before chopping him up like the others said.
It would be more even if Deadpool could regenerate a lot quicker though, when he gets his limbs cut off he has to grow new ones which take a few hours IIRC.
Problem is Blade is so much better then him that Wade will be Sashimi before he even knows what hit him.