Tough question... I do really like the Enterprise E but I have a feeling a wraith hive ship would win the battle. They would severly damage the warp narcles and the outer surface where the hive ship would just reheal it's self.
A Hive Ship has potentially hundreds if not more fighter darts. The Enterprise wouldn't stand a chance, unless of course they beamed a nuke over on to the wraith ship in which case easy win, but I doubt they would do that at all. Even as a last resort. What would be an interesting fight is a Hive Ship vs a Borg Cube.
When the darkness comes, keep an eye on the light no matter how far away it seems.