I'd assume that it's Heath Ledger's last major motion picture will help. But I'm not sure it will take the opening weekend record.
Where did you get information that it was the biggest opening day box office gross ever? Box Office Mojo only has that it's the widest release ever opening at a hair's breadth more theatres than POTC3.
The most impressive thing, is that this movie is not a kids movie, at the theater I went to, I saw no children, it was all older teens and adults. It's success isn't an example of marketing to a child, and the child dragging his parents to see it by whining a lot, it's an example of most everyone that goes, is genuinly wanting to see the movie. It was a completely different atmosphere than a typical superhero movie.
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Just to clear it up, this won't be Heath Ledger's last movie. His footage from the upcoming The Imaginarium of Doctor Parnassus is still being used. That will officially be his final film.
You have to dissect the numbers. Yes, biggest opening weekend ever, but when you account for ticket prices, last year's Spider-Man 3 actually sold more tickets. Inflation means there will always be the "next big thing" in box office gross. Just like it's inevitable that Titanic's 600Mil (US domestic) and Billion+ worldwide are also destined to be broken. Just as inevitably, it'll be a movie that sold less tickets.
The most tickets sold to a movie ever (US domestic, I don't have those stats for worldwide) was Gone With the Wind. Almost a century of movies, and it has yet to be topped.