We've had a lot of Destroyer-vs threads lately; I figured this match-up was inevitable. Still, I'll make it a little more interesting.
How would the Destroyer do against Sentry if...
1) YOU were animating it.
-- or --
2) if a tactical fighter (Batman, Iron Man) were animating it...
-- or --
3) does it even matter?
Personally, I don't think it matters, though a tactical mind would make the job go faster.
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Shinier than a speeding bullet.
Personally I tend to think it really doesn't make that big a difference as the power difference between the Destroyer and just about anybody else would be enough to ensure victory. Also the Destroyer's programming would take over in most cases no matter who is using it.
"The Destroyer was mystically endowed by Odin with its own intelligence and personality and was "programmed" by Odin to battle and to destroy, especially to destroy the first being it sees on becoming activated. Usually, a human being or Asgardian who projects his or her life force into the Destroyer will be unable to assert his or her own sentience over that of the Destroyer itself. Hence, that human being or Asgardian will be unable to control the Destroyer. Only Odin, Thor, and Loki have proved capable of subjecting the Destroyer's will to their own after each used his own life force to animate the Destroyer."
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Carl - "No, the real point is: I don't give a damn."
Carl - "This line, here? Line of Death. You cross it, and your freedoms no longer exist. Um-kay? Have a good day."
1) the destroyer would totally override my mind and do as it does best, destroy.
2) batman and the like most likely aren't powerful enough to take control of the destroyer, thor had to battle it in his mind to take control, batman can't hope to win that fight.
3) it matters cause only a select few have been able to control it fully:
-thor
-odin
-loki
-garm
-desak
BUT....anyone else who has animated it gets warped into a violent being (like the hulk) and their violent repressed emotions/memories get used by the destroyer.
if batman were to animate the destroyer armour the murder of his parents will be the only emotion he will be able to express and the destroyer will use it as fuel to keep destroying things....namely the sentry.
the destroyer's weakness is the soulless body that animates it, the destroyer's consciousness tries to prevent anything from harming the body because if the persons body dies, their soul dies as well and the destroyer is inert again.
Doesn't matter, Asgardian Destroyer will kill Sentry. If Thor can't defeat it what makes you think that Sentry can do any better. Thor has teleport the last time he fought Destroyer (Thor vol.2 1-3) it Killed Thor with it's Disintegration Beam, basically Sentry is dead as horse sh**.