Ironfist, Luke Cage. & Black Panther has never defeated fliers or people with a variety of abilities? Black Panther has daggers teleportation and anti-metal claws so couldn't Black Panther teleport to one of them and cut rip at there eyes to blind them? Can they hurt Luke Cage physically?
Yes, they also have shields that can withstand adamantinum claws and nukes. Plus physically Vindicator was taking it to Wonder Man. The duo can ALSO teleport too, while Mac can but Vindicator has a trick that's like teleportation.
Vindicator actually killed Snowbird in Sasquatch form with a single blast. They would not fair any better.