Considering how powerful the Beast is at this moment, I'll give it to The Hand. They'll simply kill all the Weapon Xers one by one and resurrect them as Hand ninjas.
I mean if you've got Tarantula at his classic levels and both DD and Elektra amped up to the point of being the best fighters in Marvel, the Hand are unbeatable.
__________________ Land of the free, home of the brave...
Do you think we will ever be saved?
In this land of dreams find myself sober...
Wonder when will it'll all be over...
Living in a void when the void grows colder...
Wonder when it'll all be over?
Will you be laughing when it's over?