Although factor in Selene's best speed and skill feats, I reckon she would win with weapons.
Marcus doesn't show a lot of skill probably because he thought he was untouchable anyway. If he fights with his "blow for blow" style he will lose.
Even with Michael alongside Marcus, it would probably be an uphill battle. If they fight smart I can see them winning, definitely not by their normal slashes or blows though. Marcus/Michael will need to impale the Lycan's head or rip it off if thats possible.