The Inquisitors decide to turn on the politician in charge of the Galactic Empire as of ANH; can they kill him in an open space starting at 30 meters away if he has a squad of elite storm troopers surrounding him and saber resistant armor on?
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Speaking as someone who regularly emphasizes the value of numbers... of course he can handle this. There's only four of them, and they aren't that strong.
Darth Krayt was in a similar position, except four Imperial Knights > four Inquisitors. And that took, like, two seconds.
Darth Sidious is stronger than Darth Krayt. And heck, the three of the B-team he killed are also stronger than the Inquisitors solidly.
Plus, you gave him stormtroopers! Which *do* help reduce the effect of numbers advantage (see: The Conclave at Kessel, where some stormies helped save Darth Vader from multiple Jedi Masters).