depends what Deadpool is packing... grenades are good to start off with but his uzi's wont do much his swords can help him dice and slice tendrils but at the end of the day he needs big explosions and fire incendiary attacks.
his plastique, self destruct harness, giant missiles and the other building leveling explosives he carries from time to time might come in handy for a few wins but he doesnt really carry them that often unless we allow him his comical 4th wall power and asinine dues ex machina weaponry