Yes. As I recall, Goku's Kamehameha against Piccolo Jr. was also stated to be strong enough to destroy the moon, and Vegeta was able to match a stronger one. It stands to reason that he could do it.
That being said, I don't think SS Vegeta could destroy 100 moons with a casual blast just because Piccolo (whose power level was ~100x lower) was able to destroy one that way. That doesn't meet my standard of evidence.
Collateral damage is different than the x amount of power needed to do something.
Destroying 100 moons is different than firing a blast 100 times more powerful than a typical moon destroying blast. It doesn't mean their collateral damage grows and their power spreads out, but it does mean the focal point of their energy is tremendous.
Go on then. Because your point was purely made about collateral damage.
"Casual" now I imagine?
Wherever DB characters focus their blast is going to be where the damage is. If they decide they want MUI Goku releasing everything he has into a house destroying attack, then we don't downplay his actual power just because his extent was minimal. We know for a fact that the energy contained within was many times stronger than say Cell's solar system buster. It's just where they choose to direct it or where to spread it out.
And if Goku is thousands of times stronger than Roshi, then it's pretty fair to say he's thousands of times stronger than a moon buster, no? I don't get where the issue is.
I didn't say you did beyond assuming you'd move onto "casual", and that your prior difficulty was with "100 moons".
3rd and 4th paragraphs are about clarification of how it works, not saying that's what you said.
Go ahead and clarify the point I missed though. Where do your issues lie here so I can try my hand at answering them?