For decades, the Govt. has worked hand in hand w. the Hollywood Illuminati, churning out alien contact/invasion movies to prepare us for this happening in RL, and it started w. Close Encounters of the Third Kind in order to deflect suspicion from a similar event that had happened a few years prior, in the early Seventies. (please log in to view the image)
Never bothered to see if this is a widely known thing on the interweb, but a theory I've always had is that Eric Cartman subconsciously uses the Anti-Life Equation.
The kid has an lengthy history of being able to compel masses of people to follow his every whim, regardless of how ridiculous or illogical his 'plans' might be. He speaks, and people just... Listen.
There's also the fact that Darkseid is technically part of South Park canon: https://ibb.co/Wgst3C3
So the ALE is conceivably something that Cartman might have access to as well.
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"I am tired of Earth. These people.
I am tired of being caught in the tangle of their lives."
So I was watching an old episode of unsolved mystery with Robert Stack and it was based on 1950s FBI undercover operation about military bio viruses that were used as a form to control population and get rid of the enemies. It made me immediately think of Corona viruse and how it just randomly appeared. This made me think of a slider episode where there was a virus that had spread and people had to sanitize because they were falling I'll.
And that Pitt's character becomes one of Batman's villains due to the extreme grief of his pregnant wife being beheaded and spending time in Arkham Asylum.