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Charles Xavier was born to a wealthy Gotham family. One day, when he was 8 years old, his parents were brutally murdered in a robbery, which scarred Charles forever. He dedicated his life to avenging their death by learning the martial arts, and once his telepathy developed, was able to learn faster than anyone had ever done so before by learning all the moves directly from the minds of the masters. He came to MASTER every martial art known in man in record time, surpassed only by his telepathic might. One day, while seeking an old Master Sage, he fell through a hole in the ground and discovered the Crimson Gem of Cyttorak, granting him the powers of a living Xbaternaut!

Or:

Xavier with his own telepathy and intelligence with Juggernaut's powers and Batman's martial arts skills vs.

Dr. Doom
Magneto
Superman
Thor
Apocalypse
Silver Surfer
Uber Cable
Thanos
Gladiator

How do they beat him when his only weakness - his mind - is finally fortified by the might of Xavier and his body is used with the skill of Batman?

BAH to this...

Too much to think about?

This was somewhat done already in the "What if Professor Xavier of the X-Men became Juggernaut."

He stifled human's outright voice of hatred against mutants and mutants took advantage of the lax environment. He created a dictatorship where his voice was to go unchallenged by any party and the only way he could be defeated was when an army of superheroes teamed up to knock him out into the atmosphere where he would endlessly drift.

With the bulk of Juggernaut, this will stifle his movement to make use of his martial arts skills, except higher alert to his surroundings. With his helmet in place, this will also negate his telepathic abilities, until he takes it off.

I wonder if the Cyttorak can enhance a person beyond just strength and durability, such as mental range and strength for Xavier. If so, most of the specified players would not lay a finger on him.

Did Xavier still have his telepathic abilities during that story? I imagine that even if he couldn't use it offensively anymore (and he should be able to), you can't do the old, "remove helmet, mind-blast Juggy" trick anymore. In fact, it now becomes, "remove the helmet, Juggy mind-blasts YOU".

I also imagine that Xavier probably couldn't use any acrobatic martial arts anymore, but his ju-jitsu, aikido, chin-na, sambo and greco-roman wrestling skills will definitely come in handy.

To what I remember, he always had his helmet on and merely used his muscle and not telepathic skills in the fight.

In normal continuum, he was actually not shabby fighter either. Maybe, he did not have the repetoire you specified, but he certaintly wasn't a pushover. Marko couldn't lay a finger on his "jack of all trade" step-brother (i.e. Xavier won a number of awards, including athletic categories).

Ya i think xavier will kick everyone in that list if the Cyttorak increase his mind power also , but if it doesn't inscrease his mental power. Thanos can beat him , and silver sulfer will put up a fight the rest are dead.

I don't understand

Can someone explain to me how Bedlam was able to assault Juggernaut's mind through his helmet in Juggernaut: 8th day

lol!

Xavier was still able to use his telepathy when he had the helmet on. I guess it worked like a one sided mirror, his powers could get through, but no one else's could.

Have we ever seen a human probe the mind of Silver Surfer
or Thanos?

If Jugg-X can't to either one of these two, then Jugg-X dies.

"Blow him straight to Hell!"-Evan Thorley

Actually, I don't think his bulk would be that much of a hindrance to his fighting. Cain was already one big SOB, and it augmented that mass. It might only make Xavier a bit bigger. Besides, the increase in physical strength would make up for any extra mass.