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Who wins?

The Lizard would have no chance against the Invisible Woman. She is just too darn powerful.

Mr.Fantastic.He would kill Lizard and In.Woman wouldn't be a problem.

But once Invisible woman punches him, he'll know that she's on front of him.

Sue and Reed can handle Lizard.

Indeed.

IW and Mr. F. There's is no way to argue this fight in favor of Lizard. No matter what you say. Mr. F and his woman have been fighting together for years and are totally in sync. And you're only going to throw 1 enemy at 'em?

a more even fight would be lizard and mister fantastic against invisible woman....... but she'd still probably win

Sue and Reed.