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Can he even catch either of them?

He might not be able to catch Flash but WW is out if not dead.

But she can fly and throw stuff

And Lobo can beat the heck out of Superman, and heal faster then she could hurt him.

You guys need to read Lobo #50. A dream type story where Lobo kills Flash.

He's strongert han ther are, and can't be killed.

So unless Wonder Woman and Flash run away, they
would almost certainly lose.

Running away is still losing.

Yeah, but better than getting beaten to death.

I'll give you that.