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Cosmic Four:

Thanos
Silver Surfer
Darkseid
Orion

VS.

Tyrant(Normal Powered)

Cosmic Four have 1 week of prep. Tyrant doesn't.

Who takes it?

Debate.

Tyrant...with the exception of Thanos, those guys r insects to Tyrant.

From what I've read..Tyrant.
Thanos is just as insect as the rest of them.

Thanos would have been squashed if he handn't run away in his fight against Tyrant