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the good doctor has decided thanos is too dangerous. he trusts no one else to do the task. he gives himself 6 weeks of prep. thanos gets none. doom pounces on him as thanos is visiting the grave of the fallen captain mar-vell. thanos is taken by surprise.

can doom do what no one else has been able to do and end thanos forever?

Probably yes.

No...he can't. Doom is as to Thanos of Titan as Earth is to the universe.

Now, if Doom could convince Big G to imbue him with the Power Cosmic, and has like, 10,000 years to practice using it, then maaaaybe.

Not the first time when Doom would take down cosmics. Beyonder, Silver Surfer, Magus...

hmm, i don't know. with less time he took down the damn-near all-powerful beyonder . . .