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I'm gonna have to go with Itachi Uchiha!

Vash the Stampede wins this

Have you seen his gun??

his beam destroyed the whole city and created a big hole in the moon. Itachi can't survive that

in h2h itachi wins

and one other thing is.. what is this doing here??

it is a ''game versus'' not an ''anime versus''

Vash wins, Itachi's mangekyou sharigan can be countered by closing your eyes how lame.

Neither originate in a game.

Closed.