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Frank Castle from Punisher: War Zone vs Dr. Connors from Amazing Spiderman.

.Frank has a steel brass knucle, two full auto Beretta M92FS Inox with 200 rounds, his S&W M500 Custom with 60 magnum rounds, supressed custom Colt M4A1 Carbine with foregrip, Eotech 552 holographic sights , Beta-C Mag and 500 rounds of 5.56x45 green tip armor piercing rounds, Franchi PA3 short barreled shotgun with 50 12Gauge Slugs, Cobray CM79LF 37mm Grenade Launcher with 6 grenade shells a 5 Gallon Gas Can and a Zippo lighter .

.Win by death

The fight takes place on the same place that the SWAT team gunned down The Lizard. They starts against each other from 40 meters.

if he has prep with the with the area and booby traps (lol i said "traps" with a few grenade shells and the 5 gallon gas can then he stands a good chance

he is armed to the teeth pretty well and does alright with standared fire arms, shotgun and machine guns so eh could be a good long fight

Bump.

I love the Punisher and even I gotta say the best he could hope for here is to escape alive. Outside of major prep with high explosives, Frank is losing this one.
The Lizard is too fast and strong to face directly even when armed to the teeth.

The Punisher is my favorite Marvel character, but as much as I love him he has no hope of winning against the Lizard.

Castle meets his maker

Frank dies. War Zone Punisher was a beast, but he isn't on a level where he could take on the Lizard.