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Venom. A smart fighter controlling the symbiote would decimate Colossus before he could land a hit. Same strength if not stronger, faster by a huge margin, instant regent as fast or faster than Wolverine and Deadpools, and tendrils and infinite number of melee weapons that can cut and smash Colossus.

When Angel had him with that steel cable she was cutting into his throat. That leaves me to believe Venom could straight up decapitate him.

Venom 10/10.,Colossus has no way of hurti g him.

Eddy kills him