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This is in New York City.

Well apparently Vision can alter his body's size and density. So the better question is, can Venom and she-venom fight against a 90 ton mass O' Crystal which is capable of emitting beams of infrared and microwave radiation, with temperatures ranging from 500 to 30,000 degrees Fahrenheit.
I know venom's are good against heat, but this just seems a little bit like a flash fry.

Depends on which Vision. The new Vision doesn't have any experience.