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Doh, meant to title it "vs Sinister 11", Oh well
So it occured to me that out of the all the Sinister 6 incarnations, there are 3 guys who seem to be playing below their means. Lets take these 3 and put them against the rest and see what happens. Standard gear for all, no CIS.

Electro, Sandman, and Aquaman
vs
Green Goblin, Dr. Octopus, Shocker, Venom (we'll say Brock), Scorpion, Mysterio, Kraven, Vluture, Hammerhead, Tombstone, and Hobgoblin.
If they clear it, lets toss in Spider-Man and Rhino as well just for fun.

My personal thought is Electro and Aquaman alone can do mass damage by combining powers. Sandman I think could handle the guys who last through the initial storm