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Round 1: Surface of the Moon
Round 2: Mephisto's realm

Can Thor with the full Odinforce and the Runes take down Mephisto?

RKT > Odin = Dormammu > Mephisto

I would say Dormammu was more powerful than Odin, personally. I think RKT has the first match in the bag, but I'm not sure if the second round would be a slim victory or a stalemate.

dormammu=odin
dormmamu said it him self

But now I -- Dormammu, Lord of Chaos, the equal of Odin or Zeus -- have died and been born again! Here! Now -- this world is mine!"

mephisto outside his relam is a joke
but inside it he is abstract level in power
he would beat rune thor with no PIS

RKT

Thor wins.

1st fight RKT.2nd not sure.

The more I think about it the more I feel RKT could take a majority in Mephisto's realm. I'm voting RKT in both rounds.

RKT could last a minute (maximum a minute) against demogorge. Demogorge punked all the death gods (including mephisto) in their own realm at the same time.