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Can she beat them?

Fight on a bamboo forest.

Grifter.

she was fighting on equal ground with midnighter, or at least close enough that grifter, even without the tele/tk would probably tip the scales

Pretty much.

Midnighter distracts her long enough for Grifter to shoot her from behind.

Z actually took it easy on Midnighter in that fight, she can amp to higher levels than that via mystical amping. At her best without holding anything in reserve she takes em both out.