Lol I would pay to see this fight and have Supergirl heat vision Medusa's hair.
leonidas
there must have been an instance of medusa's hair being ripped or torn. if there isn't, there would be one here.
crys is more of the issue, but her durability sucks. i'd think one thunderclap from the air would kill both, tbh. and i see no way for them to counter a speed blitz. in a book it might make for a cool enough fight, in a forum setting she pretty much murders the inhumans.
Q99
Even though Crystal has the stronger powers, Medusa tends to be the more effective in combat Not that it matters here.
HandOfFate
LOL, I read this just to see what handicap the OP would give Supergirl for this fight.