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Chameleon with shapeshifting powers and Kraven serum.

Upgraded Mystique (pre-death).

http://media.comicvine.com/uploads/2/23171/655458-chameleonstand.gif

vs.

http://media.comicvine.com/uploads/0/5586/1851807-mys2.jpg

bump

Does Mystique have any weapons?

Only the ones she can make using her power.

Without Chameleon having the serum I see her taking him out.
With the serum I see her losing.

It didn't work on him as good as it did on Kraven.

Dmetri has taken it to spiderman, so I give him an edge

Mystique. Skill + healing + more brutal.
Although Chameleon recently defeated Taskmaster's daughter (the one from AA) and displayed superhuman speed/agility also ability to copy moves ala Taskmaster. So its gonna be a good fight.