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Last time I put him against the guardians and he stomped them. This time I'm upping the stakes and seeing how far he gets.

The fault has just opened. Marquis is interested and quickly decides to go **** them up. How long/far does he get?

Also, if he were to learn that Thanos is the key would Cancerverse stand any chance?

He would stomp the shit out of them.

Even the Galactus Engine and Lovecraft style in between Gods?

Yes. Even them.

MoD cleans house.

MoD in a mere 5 seconds